G-csf liquid formulation

Details G-csf liquid formulation G-csf liquid formulation

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 9/06 (2006.01)

Patent

CA 2644461

The invention relates to G-CSF liquid formulations that have a long shelf-life and to methods for producing the same. The invention also relates to liquid formulations containing G-CSF as the active substance, acetate as the buffer substance, polysorbate 20 or polysorbate 80 as the surfactant and optionally pharmaceutically acceptable adjuvants, the formulations having a pH between 4.1 and 4.4.

La présente invention concerne des formulations liquides de G-CSF stables au stockage ainsi qu'un procédé de production desdites formulations. Cette invention concerne en particulier des formulations liquides contenant le facteur G-CSF comme principe actif, un acétate comme substance tampon, le polysorbate 20 ou le polysorbate 80 comme tensioactif et éventuellement des substances auxiliaires pharmaceutiquement acceptables, lesdites formulations présentant un pH compris entre 4,1 et 4,4.

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