C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) C07K 14/535 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2326755
The invention relates to agonist molecules which specifically bind to or interact with human G-CSF receptor and dimerize the receptor or activate phosphorylation of kinases associated with the receptor to stimulate cell proliferation and differentiation. Such agonist molecules include monoclonal antibodies, or fragments, homologues or analogues thereof, or peptides or organic compounds. Two examples of mouse monoclonal agonist antibodies are disclosed: mAb163-93 and mAb174-74-11.
Cette invention concerne des molécules agonistes qui se lient de manière spécifique avec le récepteur humain G-FSC ou qui interagissent spécifiquement avec ce dernier et qui dimérisent le récepteur ou activent la phosphorylation de kinases associées au récepteur pour stimuler la prolifération et la différenciation cellulaires. Ces molécules agonistes comprennent des anticorps monoclonaux ou bien des fragments, des homologues ou des analogues de ces derniers, ou bien encore des peptides ou des composés organiques. Deux exemples d'anticorps agonistes monoclonaux de souris sont présentés: le mAb163-93 et le mAb174-74-11.
Ni Baofu
Sun Bill N.c.
Sun Cecily R.y.
Sim & Mcburney
Tanox Inc.
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