G-motif oligonucleotides and uses thereof

Details G-motif oligonucleotides and uses thereof G-motif oligonucleotides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 39/39 (2006.01) A61K 45/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2341338

The present invention relates to a composition comprising an oligonucleotide comprising (a) the sequence N1-N2-G-N3-G, wherein N1 represents any nucleotide if N2 and N3 are G; N2 represents any nucleotide if N1 and N3 are G; and N3 represents any nucleotide if N1 and N2 are G, or (b) the sequence of (a), wherein at least one nucleotide is replaced by a corresponding nucleotide analog or derivative. The present invention further relates to the use of the composition, and/or the oligonucleotide of the present invention for the production of a pharmaceutical composition for preventing or treating septic shock, inflammation, autoimmune diseases, TH1-mediated diseases, bacterial infections, parasitic infections, viral infections, spontaneous abortions, and/or tumors.

L'invention porte sur une composition composée d'un oligonucléotide comprenant (a) la séquence N¿1?-N¿2?-G-N¿3?-G, dans laquelle N¿1? représente tout nucléotide si N¿2? et N¿3? sont G; N¿2? représente tout nucléotide si N¿1? et N¿3? sont G; et N¿3? représente tout nucléotide si N¿1? et N¿2? sont G, ou (b) la séquence de (a), dans laquelle au moins un nucléotide est remplacé par un nucléotide correspondant analogue ou dérivé. L'invention porte en outre sur l'utilisation de la composition, et/ou du susdit pour la production d'une composition pharmaceutique destinée à prévenir ou traiter le choc septique, les inflammations, les maladies auto-immunes, les maladies induites par le T¿H?1-, les infections bactériennes, les infections parasitaires, les infections virales, les avortements spontanés, et/ou les tumeurs.

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