G-protein coupled heptahelical receptor binding compounds...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/75 (2006.01) A61K 31/16 (2006.01) A61K 31/4427 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07C 233/60 (2006.01) C07C 233/75 (2006.01) C07C 255/57 (2006.01) C07D 213/65 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2362401

G-protein coupled heptahelical binding compounds are described, e.g. compounds of the formula (I): J-M wherein J is an aromatic moiety and M is a G-protein coupled heptahelical receptor pocket interacting moiety. The compounds of the invention can be used to treat chemokine mediated disorders, e.g. neurological, immunological, inflammatory and cancer related disorders.

L'invention concerne des composés de fixation au récepteur heptahélicoïdal couplé à la protéine G, notamment, des composés représentés par la formule: J-M dans laquelle J représente une fraction aromatique et M représente une fraction interactive avec une poche du récepteur heptahélicoïdal couplé à la protéine G. On peut utiliser ces composés afin de traiter des maladies provoquées par l'intermédiaire de chimiokines, telles que des maladies neurologiques, immunologiques, inflammatoires et apparentées au cancer.

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