G protein coupled receptor agonists and antagonists and...

Details G protein coupled receptor agonists and antagonists and... G protein coupled receptor agonists and antagonists and...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2586344

The invention relates generally to G protein coupled receptors (GPCRs) and in particular to GPCR agonists and antagonists, use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with GPCRs, such as in treating conditions in which chemokine receptors play a role, e.g., sepsis, arthritis, inflammation and autoimmune diseases.

Cette invention concerne généralement des récepteurs couplés aux protéines G (GPCR) et, en particulier, des agonistes et des antagonistes des GPCR. Elle concerne également l'utilisation de ces composés et de leurs compositions pharmaceutiques, par exemple dans le traitement, la modulation et/ou la prévention d'états physiologiques associés aux GPCR, notamment dans le traitement d'états dans lesquels les récepteurs de la chimiokine jouent un rôle, lesquels états sont, par exemple, le sepsis, l'arthrite, l'inflammation et les maladies auto-immunes.

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