G protein-coupled receptor antagonists

Details G protein-coupled receptor antagonists G protein-coupled receptor antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/08 (2006.01) A61P 15/00 (2006.01) A61P 15/06 (2006.01) C07K 7/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2689373

The present invention relates to a new class of G protein-coupled receptor agonist or antagonist, which specifically binds to the receptor protein structural elements, thus altering signal transmission and subsequent physiological effects. Described herein are peptide sequences derived from the G protein-coupled receptor protein, produced by chemical methods as selective inhibitors of signal transduction associated with stimulation of the receptor by its ligand. Such peptides or molecules derived from their primary, secondary or tertiary structures may be used as effective tocolytics for the prevention of premature labor or be used for the treatment of dysmenorrhea.

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