G protein-coupled receptor-like receptors and modulators...

Details G protein-coupled receptor-like receptors and modulators... G protein-coupled receptor-like receptors and modulators...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2390078

The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

L'invention concerne des ligands de neuropeptides, des récepteurs couplés aux protéines G et des procédés pour cribler les modulateurs de l'activité des récepteurs. Les modulateurs identifiés, qui comprennent des mimétismes de ligands de neuropeptides, sont utiles en tant qu'agents biostatiques et biocidaux de portée différente allant de l'activité létale limitée aux parasites invertébrés particuliers jusqu'aux parasiticides dirigés contre les invertébrés à spectre large, qui agissent sur une gamme étendue d'invertébrés, y compris les helminthes et les insectes.

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