G protein-coupled receptor up-regulated in prostate cancer...

Details G protein-coupled receptor up-regulated in prostate cancer... G protein-coupled receptor up-regulated in prostate cancer...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 13/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2385032

A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate cancer as well as in cancers of the kidney, uterus, cervix, stomach and rectum. Consequently, PHOR-1 provides a diagnostic and/or therapeutic target for prostate cancer.

La présente invention concerne un gène (dénommé PHOR-1) qui est largement surexprimé dans le cancer de la prostate et dans les autres cancers, et sa protéine codée. PHOR-1 est un récepteur couplé à une protéine G et possède une homologie avec les récepteurs mis en oeuvre dans l'odorat. PHOR-1 est limité à la prostate dans des tissus humains normaux, et ce gène est largement surexprimé dans le cancer de la prostate, de même que dans les cancers du rein, de l'utérus, du col de l'utérus, de l'estomac et du rectum. Le gène PHOR-1 permet par conséquent de diagnostiquer un cancer de la prostate et/ou d'établir un ciblage thérapeutique.

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