G-protein coupled receptors and uses therefor

Details G-protein coupled receptors and uses therefor G-protein coupled receptors and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/79 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2312478

The invention provides isolated nucleic acids molecules, designated flh84g5 nucleic acid molecules, which encode polypeptides having high sequence homology to G-protein coupled receptors. The invention also provides antisense nucleic acid molecules, expression vectors containing flh84g5 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which an flh84g5 gene has been introduced or disrupted. The invention still further provides isolated flh84g5 polypeptides, fusion polypeptides, antigenic peptides, and anti-flh84g5 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acide nucléique isolées, appelées molécules d'acide nucléique flh84g5, qui codent des polypeptides présentant une forte hémologie de séquence avec les récepteurs liés à la protéine G. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression contenant les molécules d'acide nucléique flh84g5, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques non humaines dans lesquels un gène flh84g5 a été introduit ou perturbé. L'invention concerne en outre des polypeptides flh84g5 isolés, des polypeptides hybrides, des peptides antigéniques, et des anticorps anti-flh84g5. L'invention concerne enfin des méthodes diagnostiques ou thérapeutiques et des procédés de criblage mettant en oeuvre des compositions de l'invention.

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