G protein-related kinase mutants in essential hypertension

Details G protein-related kinase mutants in essential hypertension G protein-related kinase mutants in essential hypertension

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) C07K 14/72 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2318479

The present invention provides diagnostic tests in which to identify individuals predisposed to essential hypertension, and the genetic, cellular and biochemical tools in which to carry out these tests. The present invention also provides methods of screening substances for anti-hypertensive properties in which to facilitate drug discovery for antihypertensive agents. A wide variety of tools are provided for these purposes as well. The present invention further provides compositions and methods for normalizing sodium transport in kidney cells of individuals having essential hypertension.

L'invention porte sur des essais diagnostiques permettant d'identifier les individus prédisposés à l'hypertension essentielle, et sur les instruments génétiques, cellulaires et biochimiques servant à effectuer ces essais. L'invention porte également sur des procédés de criblage de substances aux propriétés anti-hypertension en vue de la détection d'agents anti-hypertension, pour lesquels l'invention prévoit aussi une grande variété d'instruments. L'invention porte en outre sur des compositions et méthodes de normalisation du transport du sodium dans les cellules rénales d'individus sujets à l'hypertension essentielle.

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