G-type peptides to ameliorate atherosclerosis

Details G-type peptides to ameliorate atherosclerosis G-type peptides to ameliorate atherosclerosis

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/775 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2480217

This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The peptides are highly stable and readily administered via an oral route.

L'invention concerne de nouveaux peptides améliorant un ou plusieurs symptômes de l'athérosclérose et/ou d'autres pathologies se caractérisant par une réponse inflammatoire. Dans un mode de réalisation particulier, les peptides comprennent une hélice amphipathique G* d'apolipotréine J. Les peptides sont hautement stables et facilement administrés par voie orale.

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