Gaba-steroid antagonists and their use for the treatment of...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2585359

Compounds exhibiting 3alpha-hydroxy-5alpha/beta-steroid blocking action with no or only low antagonism against the gamma-aminobutyric acid (A) receptor (GABA-A), and compounds exhibiting partial antagonism against said receptor are presented. Methods for the prevention, treatment and/or alleviation of various CNS-disorders are suggested, as well as pharmaceutical compositions for such use.

L~invention concerne des composés dont l~action consiste à inhiber les stéroïdes 3alpha-hydroxy-5alpha/bêta-stéroïdes, et n~ayant aucun ou qu~un faible antagonisme vis-à-vis du récepteur (A) de l~acide gamma-aminobutyrique (GABA-A), ainsi que des composés présentant un antagonisme partiel vis-à-vis desdits récepteurs. L~invention concerne également des procédés destinés à la prévention, au traitement et/ou au soulagement de divers troubles du SNC, ainsi que les compositions pharmaceutiques appropriées à une telle utilisation.

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