Gadolinium chelates with carboxymethyl derivatives of...

Details Gadolinium chelates with carboxymethyl derivatives of... Gadolinium chelates with carboxymethyl derivatives of...

C - Chemistry, Metallurgy

07

F

167/46, 260/237.

C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) C07D 255/02 (2006.01) C07D 257/02 (2006.01) C07F 9/6515 (2006.01) C07F 9/6524 (2006.01)

Patent

CA 1317937

ABSTRACT Chelates of gadolinium with 1, 4, 7-triazacyclononane-N, N', N"-triacetate (NOTA); 1, 4, 7-triazacyclododecane-N, N', N" tetraacetate (DOTA); and 1, 5, 9-triazacyclododecane-N, N", N"- triacetate (DOTRA) are useful as NMR contrast agents. General formulae of these compounds are as follows: (a) NOTA: Image (b) DOTA: Image (C) DOTRA: Image

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