Galanin receptor galr2

Details Galanin receptor galr2 Galanin receptor galr2

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07K 14/72 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2256523

The present invention provides a novel galanin receptor protein, the GalR2 receptor. Also provided are the nucleic acid sequences encoding this novel receptor protein as well as methods for using this protein and its nucleic acid sequence, and methods useful for developing and identifying compounds for the treatment of diseases and disorders in which galanin is implicated. The importance of this discovery is manifested in the effects of galanin, which include antinociceptive activity, smooth muscle contraction, cardiovascular activity, pituitary hormone release, cognition, and increased food intake. Thus, this receptor protein is useful for screening for galanin agonist and antagonist activity for controlling these conditions.

L'invention concerne une nouvelle protéine récepteur de galanine, appelée récepteur GalR2. On décrit par ailleurs les séquences nucléotidiques codant la protéine, des procédés d'utilisation de cette protéine et de sa séquence nucléotidique, et des procédés de préparation et d'identification de composés propres au traitement des maladies et des troubles faisant intervenir la galanine. L'importance de l'invention réside dans les effets produits par la galanine, à savoir: activité antinociceptive, contraction des muscles lisses, activité cardio-vasculaire, secrétion d'hormones hypophysaires, cognition, et apport alimentaire accru. La protéine est donc utile pour le dépistage des activités agonistes et antagonistes liées à la galanine en vue de contrôler les états correspondants.

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