Galenic composition containing opioid antagonists

Details Galenic composition containing opioid antagonists Galenic composition containing opioid antagonists

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2273353

A pharmaceutical composition for oral administration contains naloxone-, N- methylnaloxone- and/or N-methylnaltrexone-containing particles which release the active substance depending on the ambient pH. This ensures the liberation of the active substance over the whole gastrointestinal tract. The side effects caused by the use of analgesic opioids, such as constipation, are thus eliminated without reducing the analgesic effect.

Cette composition pharmaceutique à administration orale contient des particules de naloxone, de N-méthylnaloxone et/ou de N-méthylnaltréxone qui libèrent le principe actif en fonction du pH ambiant, ce qui assure la libération du principe actif dans tout le conduit gastro-intestinal. Les effets secondaires causés par l'administration d'analgésiques aux opioïdes, tels que la constipation, sont ainsi éliminés sans réduire l'effet analgésique.

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