Galenic preparation forms for oral antidiabetic agents and...

A - Human Necessities – 61 – K

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A61K 31/395 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/195 (2006.01) A61K 31/64 (2006.01)

Patent

CA 1228300

Abstract Pharmaceutical Compositions The specification describes new orally adminis- trable pharmaceutical compositions containing antidia- betic agents having an improved release of active substance and processes for producing these pharmaceu- tical compositions. The new pharmaceutical compositions are characterised in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of the metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the antidiabetically active substance in a quantity such that the active substance is made soluble, then a solubilising agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated and the residue is further processed to yield the various pharmaceutical composi- tions.

456097

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