Galenical preparation of metoclopramide, process for...

Details Galenical preparation of metoclopramide, process for... Galenical preparation of metoclopramide, process for...

A - Human Necessities

61

K

167/268

A61K 31/165 (2006.01) A61K 9/50 (2006.01)

Patent

CA 1166574

ABSTRACT OF THE DISCLOSURE A new galenic form of METOCLOPRAMIDE with delayed release of METO- PRAMIDE is provided herein. Such novel galenic form is preferably provided by microgranules comprising a neutral core formed by a grain of an inert excipient comprising at lest two of the following components, namely, saccharose starch, talc, dessicating silica, lactose and stearic acid, this neutral grain being provided with a first layer comprising METOCLOPRAMIDE. Then a second outer layer is formed by a microporous envelope comprising at least one neutral or synthetic polymer from the following, namely, shellac, gum arabic, ethyl cellulose, cellulose acetophthalate, cellulose triacetate, polyoxyethyleneglycol, the methac- rylates, styrene-acrylonitrile copolymers or polyvinylpyrrolidone, in successive envelopes. New useful medicaments for the treatment of gastric troubles are thus provided.

388666

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