Gamma-amino-butyric acid derivatives as gabab receptor ligands

Details Gamma-amino-butyric acid derivatives as gabab receptor ligands Gamma-amino-butyric acid derivatives as gabab receptor ligands

C - Chemistry, Metallurgy

07

C

C07C 229/34 (2006.01) A61K 31/195 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/505 (2006.01) A61K 31/662 (2006.01) A61P 11/00 (2006.01) A61P 43/00 (2006.01) C07C 233/81 (2006.01) C07C 311/21 (2006.01) C07D 213/60 (2006.01) C07D 233/64 (2006.01) C07D 333/04 (2006.01) C07F 9/30 (2006.01)

Patent

CA 2758245

Gamma-amino-butyric acid derivatives of formula (I) that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed. R5 is chosen from -COOH, -SOOH, and -P(O)(OH)R8 wherein R8 is chosen from hydrogen and C1-4 alkyl.

La présente invention concerne des dérivés d'acide gamma-aminobutyrique qui sont des ligands des récepteurs GABAB, des compositions pharmaceutiques comprenant lesdits dérivés, et des procédés d'utilisation desdits dérivés et desdites compositions pharmaceutiques dans le traitement de maladies.

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