C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/438 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 211/18 (2006.01) C07D 221/20 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 409/06 (2006.01) C07D 413/04 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2503720
The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
La présente invention concerne des composés de la formule (I), où R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, W, X et n ont la définition donnée. Ces composés sont utiles comme modulateurs de l'activité de récepteur de chimiokine. Ces composés sont notamment utiles comme modulateurs du récepteur de chimiokine CCR-2.
Butora Gabor
Pasternak Alexander
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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