Gamma aminobutyric acid agonists and their use in the...

C - Chemistry – Metallurgy – 07 – C

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C07C 229/34 (2006.01) C07C 229/14 (2006.01) C07C 237/06 (2006.01) C07C 237/20 (2006.01) C07C 255/24 (2006.01) C07D 213/38 (2006.01) C07D 215/12 (2006.01) C07D 277/28 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1336436

The present invention relates to compounds for use in the treatment of depression or senile dementia, which act selectively as agonists of gamma aminobutyric acid (GABA) at GABA autoreceptors, excluding the compound fengabine or progabide. Preliminary chemical trials of the antidepressant activity of such compounds suggests novel therapies for the treatment of affective disorders through interventions directed specifically at GABA transmission.

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