C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/32 (2006.01) A61K 31/55 (2006.01) A61P 9/06 (2006.01) C07D 223/16 (2006.01)
Patent
CA 2537400
The invention relates to a -Crystalline form of ivabradine hydrochloride of formula (I): ¬see formula I| characterized by its powder X-ray diffraction data. The invention also concerns medicinal products containing the same which are useful as bradycardics or for the treatment or prevention of myocardial, associated rhythm disturbances or heart failure.
L'invention concerne la forme cristalline .gamma. du chlorhydrate de l'ivabradine de formule (I) : (voir formule I) caractérisée par son diagramme de diffraction X sur poudre. L'invention vise également l'utilisation de forme cristalline .gamma. du chlorhydrate de l'ivabradine en tant que médicament ayant des propriétés bradycardisantes ou pour le traitement ou la prévention de l'ischémie myocardique, des troubles du rythme associés ou de l'insuffisance cardiaque.
Auguste Marie-Noelle
Damien Gerard
Horvath Stephane
Les Laboratoires Servier
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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