Gamma-glutamyl and beta-aspartyl containing immunomodulator...

Details Gamma-glutamyl and beta-aspartyl containing immunomodulator... Gamma-glutamyl and beta-aspartyl containing immunomodulator...

C - Chemistry, Metallurgy

07

D

C07D 209/20 (2006.01) A61K 31/405 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2316310

Synthetic immunomodulatory molecules having a .gamma.L-glutamyl-, a .gamma.D- glutamyl, a .beta.-L-aspartyl, or a .beta.-D-aspartyl moiety at the amino terminus are provided as illustrated by Formula (A). In Formula (A), "n" is 1 or 2, R is hydrogen, acyl or alkyl, and X is an aromatic or heterocyclic amino acid or its dedvative. A particularly preferred embodiment is .gamma.D-glutamyl-L-tryptophan, which has immunomodulatory activity.

L'invention concerne des molécules synthétiques immunomodulatrices comportant une fraction gamma -L-glutamyle, gamma -D-glutamyle, beta -L-aspartyle ou beta -D-aspartyle à l'extrémité N-terminale, représentées par la formule (A). Dans la formule (A), "n" est égal à 1 ou 2, R est hydrogène, acyle ou alkyle, et X est un acide aminé aromatique ou hétérocyclique ou un dérivé de celui-ci. Un mode de réalisation particulièrement préféré concerne la gamma -D-glutamyl-L-tryptophane, qui possède une activité immunomodulatrice.

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