Gamma-heregulin

Details Gamma-heregulin Gamma-heregulin

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2257839

A member of the heregulin superfamily has been identified which is designated ".gamma.-HRG". This molecule, secreted by human breast cancer MDA-MB-175 cells, leads to the formation of a constitutive active receptor complex and stimulates the growth of these cells in an autocrine manner. .gamma.-HRG polypeptide and nucleic acid are disclosed, together with various uses therefor (e.g. use of .gamma.-HRG nucleic acid for the recombinant production of .gamma.-HRG). .gamma.-HRG antagonists (e.g. neutralizing antibodies and antisense nucleic acid molecules) as well as uses therefor are also described.

Un membre de la super famille des hérégulines a été identifié et désigné ".gamma.-HRG". Cette molécule sécrétée par les cellules cancéreuses du sein MDA-MB-175, conduit à la formation d'un complexe de récepteur constitutif actif et stimule la croissance de ces cellules d'une manière autocrine. L'acide nucléique et le polypeptide de .gamma.-HRG sont divulgués, ainsi que leurs utilisations (par exemple utilisation de l'acide nucléique .gamma.-HRG pour la production recombinante de .gamma.-HRG). L'invention décrit également des antagonistes de .gamma.-HRG (p.ex. des anticorps de neutralisation et des molécules d'acides nucléiques antisens) ainsi que leurs utilisations.

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