Gamma-ketoacid dipeptides as inhibitors of caspase-3

Details Gamma-ketoacid dipeptides as inhibitors of caspase-3 Gamma-ketoacid dipeptides as inhibitors of caspase-3

C - Chemistry, Metallurgy

07

C

C07C 323/59 (2006.01) A61K 31/198 (2006.01) A61P 25/00 (2006.01) C07D 239/34 (2006.01) C07D 271/06 (2006.01)

Patent

CA 2367862

Compounds represented by formula (I):as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.

La présente invention concerne des composés de formule (I) ainsi que leurs sels, leurs esters et leurs hydrates pharmaceutiquement acceptables, et que des compositions pharmaceutiques et des procédés de traitment. Ces composés sont utiles en tant qu'inhibiteurs de la caspase-3 qui est impliquée dans la modulation de l'apoptose.

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