Gamma probe detection of amyloid plaque using radiolabeled...

Details Gamma probe detection of amyloid plaque using radiolabeled... Gamma probe detection of amyloid plaque using radiolabeled...

G - Physics

01

T

G01T 1/161 (2006.01) A61K 51/00 (2006.01)

Patent

CA 2716524

The present invention relates to a method of detecting .beta.-amyloid peptide aggregates in the brain of an individual and kits thereto. The method includes administering to an individual an effective amount of an A.beta.-binding radiopharmaceutical, waiting a period of time, measuring a gamma radiation count over an external area of the head corresponding to the cortex of the individual using a radiation detection device, and comparing the gamma radiation count with a control gamma radiation count.

L'invention concerne un procédé de détection d'agrégats de peptides ß-amyloïdes dans le cerveau d'un sujet et des kits correspondants. Le procédé consiste à administrer à un sujet une quantité efficace d'un produit radiopharmaceutique de liaison Aß, à attendre un certain laps de temps, à mesurer une quantité de rayonnement gamma sur une zone externe de la tête correspondant au cortex du sujet à laide dun appareil de détection de rayonnement et à comparer la quantité de rayonnement gamma avec un compteur de rayonnement gamma.

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