.gamma.-rar antagonist ligand or .alpha.-rar agonist ligand...

Details .gamma.-rar antagonist ligand or .alpha.-rar agonist ligand... .gamma.-rar antagonist ligand or .alpha.-rar agonist ligand...

A - Human Necessities

61

K

A61K 31/455 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/38 (2006.01)

Patent

CA 2231558

The use of at least one ligand selected from an .alpha.-RAR receptor-specific agonist ligand and a .gamma.-RAR receptor-specific antagonist ligand to prepare a pharmaceutical composition for reducing the rate of apoptosis in at least one cell population. The composition is particularly suitable for treating a disease or disorder related to an excessive rate of apoptosis in at least one cell population.

Utilisation d'au moins un ligand choisi parmi un ligand agoniste spécifique aux récepteurs de type RAR-.alpha. et un ligand antagoniste spécifique aux récepteurs de type RAR-.gamma. dans la préparation d'une composition pharmaceutique destinée à diminuer le taux d'apoptose dans au moins une population cellulaire. Cette composition peut servir notamment à traiter une maladie ou un désordre lié à un excès du taux d'apoptose dans au moins une population cellulaire.

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