C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 45/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2452832
According to the screening method of the invention substances capable of modulating .gamma.-secretase activity are identified by incubating a source and a substrate of .gamma.-secretase activity with a test substance and detecting a C-terminal fragment released from said substrate.
L'invention concerne un procédé de criblage dans lequel des substances pouvant moduler l'activité de la .gamma.-sécrétase sont identifiées par incubation d'une source et d'un substrat d'activité de .gamma.-sécrétase avec une substance d'essai, et par détection d'un fragment C-terminal libéré à partir dudit substrat.
Dorner-Ciossek Cornelia
Fuchs Klaus
Haass Christian
Kostka Marcus
Steiner Harald
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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