C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2381952
The invention relates to a method for identifying specific .gamma.-secretase inhibitors which can be used for treating neuro-degenerative diseases, in particular to a method which can be carried out in vitro. The invention also relates to a test kit which can be used for said method, in addition to the use of this test kit or method to identify substances which specifically inhibit .gamma.-secretase. A further embodiment relates to the use of these substances to produce a medicament for treating neuro-degenerative diseases and to pharmaceutical formulations which contain said substances.
L'invention concerne des procédés pour l'identification d'inhibiteurs de .gamma.-secrétase spécifiques servant au traitement d'affections neurodégénératives, en particulier des procédés pouvant être exécutés in vitro. L'invention concerne également un nécessaire pour tests permettant d'exécuter le procédé selon l'invention, ainsi que l'utilisation de ce nécessaire pour tests ou du procédé pour détecter des substances inhibant la .gamma.-secrétase de manière spécifique. L'invention concerne en outre l'utilisation de ces substances pour la production d'un médicament servant au traitement d'affections neurodégénératives, ainsi que des formulations pharmaceutiques contenant ces substances.
Fechteler Katja
Fuchs Klaus
Kostka Marcus
Boehringer Ingelheim Pharma Kg
Fetherstonhaugh & Co.
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