Gamma secretase modulators

Details Gamma secretase modulators Gamma secretase modulators

C - Chemistry, Metallurgy

07

D

C07D 233/76 (2006.01) A61K 31/4178 (2006.01) A61P 25/28 (2006.01) C07D 233/86 (2006.01) C07D 233/88 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2700964

In its many embodiments, the present invention provides a novel class of 5- membered, nitrogen-containing heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

Dans ses nombreux modes de réalisation, la présente invention porte sur une nouvelle classe de composés hétérocycliques contenant de l'azote, à 5 chaînons, comme modulateurs de la gamma secrétase, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques contenant un ou plusieurs de ces composés, sur des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés, et sur des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou plusieurs maladies associées au système nerveux central à l'aide de tels composés ou compositions pharmaceutiques.

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