Gamma secretase modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/10 (2006.01) A61K 31/4738 (2006.01) A61P 25/28 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2707712

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

Nouveaux composés qui sont des modulateurs de la gamma sécrétase. Ces composés sont représentés par la formule (I) dans laquelle R2 est un noyau bicyclique fusionné de formule (II). L'invention concerne également des méthodes de modulation de l'activité de la gamma sécrétase et des méthodes de traitement de la maladie d'Alzheimer au moyen de composés de formule (I).

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