Gamma secretase modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/04 (2006.01) A61K 31/5395 (2006.01) A61P 25/28 (2006.01) C07D 273/04 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2742486

In its many embodiments, the present invention provides a novel class of heterocyclic compounds of Group A or Group, as defined herein, as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

La présente invention concerne, dans bon nombre de ses aspects, une nouvelle classe de composés hétérocycliques du Groupe A ou d'un Groupe tel que défini dans la description, en tant que modulateurs de gamma sécrétase, des procédés de préparation de ces composés, des compositions pharmaceutiques contenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques contenant un ou plusieurs de ces composés, et des méthodes de traitement, de prévention, d'inhibition, ou d'amélioration d'une ou plusieurs maladies touchant le système nerveux central à l'aide de ces composés ou compositions pharmaceutiques.

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