Gamma secretase modulators

Details Gamma secretase modulators Gamma secretase modulators

C - Chemistry, Metallurgy

07

D

C07D 401/10 (2006.01) A61K 31/4738 (2006.01) A61P 25/28 (2006.01) C07D 403/10 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2707722

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

Nouveaux composés qui sont des modulateurs de la gamma sécrétase. Ces composés sont représentés par la formule (I) dans laquelle R2 est un noyau bicyclique fusionné de formule (II). L'invention concerne également des méthodes de modulation de l'activité de la gamma sécrétase et des méthodes de traitement de la maladie d'Alzheimer au moyen des composés de formule (I).

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