A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01) C12N 9/48 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 15/09 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2457502
Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to A.beta. peptide. Gamma three protease may be involved in the development and/or progression of Alzheimer s disease. Methods of identifying inhibitors of gamma three protease, useful in the prevention or treatment of Alzheimer s disease, are disclosed.
La présente invention concerne une gamma-3 protéase qui est une nouvelle protéase de la classe des aspartyles capable de jouer un rôle dans le processus de transformation de la protéine précurseur amyloïde (APP) en peptide A.beta.. La gamma-3 protéase peut être impliquée dans le développement et/ou la progression de la maladie d'Alzheimer. Des méthodes d'identification d'inhibiteurs de la gamma-3 protéase, utiles dans la prévention ou le traitement de la maladie d'Alzheimer sont également présentées.
Crouthamel Ming-Chih
Gardell Stephen J.
Huang Qian
Lai Ming-Tain
Li Yueming
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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