Ganglioside based vaccine compositions for subcutaneous...

Details Ganglioside based vaccine compositions for subcutaneous... Ganglioside based vaccine compositions for subcutaneous...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/70 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2535214

The invention relates to vaccine compositions which combine gangliosides and the N. meningitidis outer membrane protein complex (OMPC) in order to form very small size proteoliposomes (VSSP) which are intended for subcutaneous administration. The inventive compositions do not require the use of additional adjuvants. Said compositions enable immunological treatments with gangliosides, particularly N-AcGM3/VSSP and N-GcGM3/VSSP, which are advantageous owing to the fact that they are less aggressive at the point of injection and can be used more easily with less discomfort for patients.

La présente invention concerne des compositions vaccinales dans lesquelles sont combinés des gangliosides et le complexe de protéines de la membrane externe (CPME) de N. meningitidis permettant de former des protéoliposomes de très petite taille (VSSP), destinées à être administrées par voie sous-cutanée. Ces compositions ne nécessitent pas d'adjonction d'adjuvants. Les compositions décrites permettent d'administrer un traitement immunologique à base de gangliosides, en particulier N-AcGM3/VSSP et N-GcGM3/VSSP, et présentent des avantages du fait qu'elles sont moins agressives au niveau du point d'injection et qu'elles peuvent être utilisées de manière simplifiée et avec moins de désagréments pour les patients.

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