Gap junctions and endothelial-derived hyperpolarizing factor...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/4015 (2006.01) A61K 31/444 (2006.01) A61K 31/522 (2006.01) A61K 31/7076 (2006.01) A61K 38/04 (2006.01) A61K 47/48 (2006.01) A61P 9/00 (2006.01) A61P 9/08 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2461542

The invention relates to the permeability of gap junctions and specifically to agents which modulate same. The invention describes the use of cAMP and/or cAMP phosphodiesterase inhibitors to enhance flow through gap junctions and various synthetic peptides which attenuate flow through gap junctions.

La présente invention concerne la perméabilité de jonctions lacunaires et, spécifiquement, des agents qui modulent ces dernières. Cette invention concerne l'utilisation d'inhibiteurs de monophosphate d'adénosine cyclique (cAMP) et/ou de phosphodiestérase cAMP pour renforcer l'écoulement à travers les jonctions lacunaires et de divers peptides synthétiques qui réduisent l'écoulement à travers les jonctions lacunaires.

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