Gapped oligomeric compounds having linked bicyclic sugar...

Details Gapped oligomeric compounds having linked bicyclic sugar... Gapped oligomeric compounds having linked bicyclic sugar...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2538174

The present invention relates to bicyclic nucleosides and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity and nuclease resistance properties compared to unmodified oligomeric compounds. The oligomeric compounds are useful, for example, for investigate and therapeutic purpose.

L'invention concerne des nucléosides bicycliques et des composés oligomères comprenant au moins un tel nucléoside. Les composés oligomères présentent généralement des propriétés renforcées du point de vue de l'affinité de liaison et de la résistance aux nucléases, par rapport à des composés oligomères non modifiés. Ces composés oligomères sont utiles, par exemple, à des fins de recherche et thérapeutiques.

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