A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 49/18 (2006.01) A61K 49/22 (2006.01) B01J 13/02 (2006.01)
Patent
CA 2222186
Long lasting gas emulsions for ultrasound and magnetic resonance imaging contrast enhancement utilize low Ostwald coefficient fluoromono- and fluoropolyether compounds. Gas emulsions comprising microbubble preparations are disclosed wherein the microbubbles comprise fluoroethers such as perfluorodiglyme (CF3(OCF2CF2)2OCF3), perfluoromonoglyme (CF3OCF2CF2OCF3), perfluorodiethylether C2F5OC2F5, perfluoroethylmethylether CF3OC2F5, perfluorodimethylether CF3OCF3, as well as CF3OCF2OCF3 and fluoropolyethers CF3(OCF2)2OCF3, CF3(OCF2)3OCF3, and CF3(OCF2)4OCF3.
Selon cette invention, on utilise des composés de fluoromonoéthers et de fluoropolyéthers à faible coefficient d'Ostwald dans des émulsions gazeuses à longue durée de vie pour améliorer le contraste dans les techniques d'imagerie par résonance magnétique et par ultrasons. Ces émulsions gaseuses comprennent des préparations à microbulles, dont les microbulles contiennent des fluoroéthers, tels que perfluorodiglyme (CF¿3?(OCF¿2?CF¿2?)¿2?OCF¿3?, perfluoromonoglyme (CF¿3?OCF¿2?CF¿2?OCF¿3?), perfluorodiéthyléther C¿2?F¿5?OC¿2?F¿5?, perfluoroéthylméthyléther CF¿3?OC¿2?F¿5?, perfluorodiméthyléther CF¿3?OCF¿3?, ainsi que CF¿3?OCF¿2?OCF¿3? et fluoropolyéthers CF¿3?(OCF¿2?)¿2?OCF¿3?, CF¿3?(OCF¿2?)¿3?OCF¿3?, et CF¿3?(OCF¿2?)¿4?OCF¿3?.
Kabalnov Alexey
Schutt Ernest George
Weers Jeffry Greg
Alliance Pharmaceutical Corp.
Imcor Pharmaceutical Co.
Sim & Mcburney
LandOfFree
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