A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/22 (2006.01) A61K 41/00 (2006.01)
Patent
CA 2456988
Formulations comprising a gas microsphere liposome composite suspended in a medium, wherein the gas microsphere liposome composite comprises: a gas-filled microsphere; at least one of a lipid and a surfactant adsorbed onto the surface of the gas-filled microsphere; and liquid-filled liposomes attached to the lipid or surfactant are described. Methods of preparing the same and using them in ultrasound imaging are also described. The present invention also comprises use of the same in treating heart disease, inflammation, infection, cancer or thromboembolic disease in a patient
L'invention concerne des compositions contenant un composite de liposomes à microsphère de gaz suspendu dans un milieu. Ce composite de liposomes à microsphère de gaz comprend: une microsphère remplie de gaz; au moins un lipide ou un tensioactif adsorbé sur la surface de ladite microsphère remplie de gaz; et des liposomes remplis de liquide liés au lipide ou au tensioactif. L'invention concerne également des procédés permettant de préparer lesdites compositions et de les utiliser dans l'imagerie par ultrasons. L'invention concerne également l'utilisation de ces compositions dans le traitement des maladies cardiaques, des inflammations, des infections, des cancers ou des maladies thromboemboliques.
Carpenter Alan P. Jr.
Slack Gregory C.
Bristol-Myers Squibb Pharma Company
Gowling Lafleur Henderson Llp
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