A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 33/00 (2006.01) A61M 1/14 (2006.01) B01D 67/00 (2006.01) B01D 69/12 (2006.01) C12N 11/06 (2006.01) A61M 1/16 (2006.01) A61M 1/36 (2006.01)
Patent
CA 2080229
2080229 9115952 PCTABS00007 The present invention is directed to thrombo-resistant coatings for use with gas permeable biomedical devices and implants. The coatings include a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A quantity of at least one bioactive molecule designed to counteract a specific blood-material incompatibility reaction is covalently bonded to the poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The methods of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is preferably achieved by plasma etching with ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a solution of at least one bioactive molecule which counteracts a blood-material incompatibility reaction, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface is capable of resisting blood-material incompatibility reactions while maintaining high gas permeability.
Berry Gaylord
Mortensen J. D.
Sanders Clifton G.
Solen Kenneth A.
Winters Suzanne
Barrigar & Moss
Cardiopulmonics Inc.
LandOfFree
Gas permeable thrombo-resistant coatings and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gas permeable thrombo-resistant coatings and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gas permeable thrombo-resistant coatings and methods of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1791413