Gas-target method for the production of iodine-123

Details Gas-target method for the production of iodine-123 Gas-target method for the production of iodine-123

G - Physics

21

G

359/16

G21G 1/10 (2006.01)

Patent

CA 1201222

ABSTRACT Charged-particles in the 45 - 15 MeV energy range incident upon isotopically enriched xenon-124 gas in a gas-target assembly cause nuclear reaction which yield radioactive xenon-123. The venon-123, decaying either in the target assem- bly or in a decay vessel removed from the target assembly; yields iodine-123 with very low levels of radioactive contamin- ants. LITERATURE SURVEY There are many publications concerned with the production of iodine 123. Three reviews are given by: Sodd et al, Isotop. Radiat. Technol. 9 (1971/1972) 154-159, "Evaluation of Nuclear Reactions That Produce I-123 in the Cyclotron"; Weinreich, Proceedings of the Panel Discussion, "Iodine-123 in Western Europe. Production, Application, Distribution", Julich, Feb. 13, 1976, "Critical Comparison of Production Methods for Iodine-123", pages 49-69; Van den Bosch, Thesis, Technische Hogeschool Eindhoven, The Netherlands, Oct. 1979. "Production of I-123, Br-77, and Y-87 with the Eindhoven AVF Cyclotron". The applicability of iodine-123 to diagnostic studies and its advantages over other radioiodines are outlined in these reviews and by Myers et al, Radiopharmaceuticals and Labelled Compounds, Vol. 1, Vienna, IAEA/SM-171/34, 1973, "Radioiodine- 123 for Applications in Diagnosis". Iodine-123 production routes may be divided into two general categories. The first concerns nuclear reaction pathways which form iodine-123 directly, such as the reaction 124Te (p, 2n)123I.

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