Gas57 mutant antigens and gas57 antibodies

Details Gas57 mutant antigens and gas57 antibodies Gas57 mutant antigens and gas57 antibodies

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2699513

The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.

La présente invention concerne des mutants de l'antigène GAS57 qui se révèlent incapables de cliver l'IL-8 et les substrats similaires, mais qui conservent la capacité d'induire une protection contre S. pyogenes. L'invention concerne également des anticorps se liant, de façon spécifique, à l'antigène GAS57 et inhibant sa capacité à cliver l'IL-8 et les substrats similaires. Ces mutants se révèlent utiles, entre autres, dans les compositions vaccinales destinées à induire une protection contre S. pyogenes. Les anticorps se révèlent utiles, par exemple à des fins thérapeutiques, en vue du traitement d'infections causées par S. pyogenes.

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