Gasc1 gene

Details Gasc1 gene Gasc1 gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2411249

The invention provides, for example, a gene comprising a polynucleotide coding for the polypeptide having the amino acid sequence shown in SEQ ID NO:1. The gene shows amplification in the 9p23-24 region, has a PX domain and PHD finger motifs, plays an important role in cell growth and differentiation, and in tumorigenesis, and is useful in elucidating the pathology of various diseases caused by a protein involved in cell differentiation in malignant tumor or the like, and in the diagnosis and treatment of such diseases.

L'invention concerne un gène renfermant un polynucléotide codant un polypeptide présentant une séquence d'acides aminés représentée par, par exemple, SEQ ID NO: 1. Ce gène, présentant une amplification dans le domaine 9p23-24 et possédant un domaine PX, ainsi qu'un motif doigt PHD, joue un rôle important dans la prolifération et la différentiation cellulaires, ainsi que dans la formation d'une tumeur. Par conséquent, ce gène est utile pour la clarification des états pathologiques de différentes maladies associées la différentiation cellulaire (tumeur maligne, etc.), le diagnostic et le traitement de ces maladies, etc.

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