A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 49/22 (2006.01)
Patent
CA 2223994
Inhalable ultrasound contrast imaging agents that are capable of forming microbubbles in vivo after administration to a patient are provided. The imaging agent is comprised of a gaseous mixture of an insoluble perfluorocarbon gas and at least about 20 % oxygen by volume that is administered by a standard inhalation apparatus. Carbogen may be mixed with the insoluble perfluorocarbon gas in an amount sufficient to provide 20 % oxygen by volume in the final gaseous mixture. A method of ultrasound imaging an individual by administering the gaseous composition of the invention to an individual by an inhalation apparatus and then subjecting the individual to an ultrasound scan is also provided.
Cette invention se rapporte à des agents d'imagerie de contraste aux ultrasons pouvant être inhalés, qui sont capables de former des microbulles in vivo après administration à un patient. Cet agent d'imagerie est constitué par un mélange gazeux d'un gaz de perfluorocarbone insoluble et d'au moins 20 % d'oxygène en volume, qui est administré par un appareil d'inhalation standard. Du carbogène peut être mélangé au gaz de perfluorocarbone insoluble selon une quantité suffisante pour fournir 20 % d'oxygène en volume au mélange gazeux final. Cette invention concerne également un procédé pour effectuer l'imagerie par ultrasons du corps d'un sujet en lui administrant cette composition gazeuse au moyen d'un appareil d'inhalation, puis en soumettant ce sujet à un balayage aux ultrasons.
Mallinckrodt Inc.
Mallinckrodt Medical Inc.
Osler Hoskin & Harcourt Llp
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