Gastric acid secretion inhibiting composition

Details Gastric acid secretion inhibiting composition Gastric acid secretion inhibiting composition

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 31/341 (2006.01) A61K 31/4164 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2501201

An oral pharmaceutical dosage form comprises pharmacologically effective amounts of an acid-susceptible proton pump inhibitor and an H2 receptor antagonist in combination with at least on pharmacologically acceptable excipient which causes a delayed release and/or an extended release of the proton pump inhibitor. The H2 receptor antagonist is included in the dosage form in such a way that it is rapidly released after administration. This dosage form is suitable for the treatment of conditions associated with an excessive secretion of gastric acid and provides a suitable combination of a rapid onset and a long-lasting duration of the effect. The invention also relates to a method for manufacturing such a dosage form and to a method for the treatment of conditions associated with the secretion of gastric acid.

L'invention concerne une forme posologique orale, qui comprend des quantités pharmacologiquement efficaces d'un inhibiteur de la pompe à protons sensible à l'acide et d'un antagoniste du récepteur de H2, associés à au moins un excipient pharmacologiquement acceptable qui provoque une libération différée et/ou une libération prolongée de l'inhibiteur de la pompe à protons. L'antagoniste du récepteur de H2 est inclus dans la forme posologique de façon à être libéré rapidement après administration. La forme posologique de l'invention convient pour le traitement d'affections associées à une sécrétion excessive d'acide gastrique et combine les effets appropriés d'un déclenchement rapide et d'une action durable. L'invention concerne en outre un procédé de production de ladite forme posologique et une méthode de traitement d'affections associées à la sécrétion d'acide gastrique.

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