A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/341 (2006.01) A61K 31/4164 (2006.01) A61K 31/426 (2006.01)
Patent
CA 2444268
An oral pharmaceutical dosage form comprises pharmacologically effective amounts of an acid susceptible proton pump inhibitor or a salt thereof, an H2 receptor antagonist or a salt thereof and a pharmaceutically acceptable carrier. The dosage form is capable of raising gastric pH to above 4 within two hours after administration and to keep it at that level for at least 4 hours. Also disclosed is a method of manufacture of the dosage form, its use in treating dyspepsia and infection by Helicobacter pylori, and a method of treating disorders associated with gastric acid secretion.
L'invention concerne une forme posologique pharmaceutique par voie orale constituée de doses pharmacologiquement efficaces d'un inhibiteur de la pompe à protons sensible à l'acide ou un sel de celui-ci, un antagoniste du récepteur H2 ou un sel de celui-ci et un excipient pharmaceutiquement acceptable. La forme posologique est capable de relever le pH gastrique au-delà de 4 en deux heures après son administration et de le maintenir à ce niveau pendant au moins 4 heures. L'invention concerne en outre un procédé de fabrication de la forme posologique, l'utilisation de celle-ci dans le traitement de la dyspepsie et d'infections à Helicobacter pylori, ainsi qu'un procédé de traitement de troubles liés à la sécrétion d'acides gastriques.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Orexo Ab
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