A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 9/46 (2006.01) A61K 31/197 (2006.01) A61K 47/38 (2006.01)
Patent
CA 2452738
The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.
La présente invention concerne un système d'administration régulée de médicament à rétention gastrique. Ce système comprend (a) un noyau à libération régulée renfermant un médicament, un polymère hautement gonflable et un agent générateur de gaz, ledit noyau pouvant rapidement gonfler et devenir flottant tout en conservant son intégrité physique dans les fluides gastro-intestinaux pendant une durée prolongée, et (b) une composition d'enrobage à libération rapide comprenant le même médicament que dans le noyau ainsi que des excipients pharmaceutiquement acceptables, cette composition d'enrobage entourant le noyau de façon que le système présente une libération biphasique du médicament dans les fluides gastro-intestinaux.
Dharmadhikari Nitin Bhalachandra
Dhavse Vaishali Vijay
Dudhara Kamlesh Mohanlal
Riches Mckenzie & Herbert Llp
Sun Pharma Advanced Research Company Ltd.
Sun Pharmaceutical Industries Limited
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