Gastric retentive gabapentin dosage forms and methods for...

A - Human Necessities – 61 – K

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A61K 31/195 (2006.01) A61K 9/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2635466

Provided is a method of treating a patient suffering from a pain state by administering to the patient a gastric retentive dosage form of gabapentin that is capable of administration in once-daily or twice daily dosing regimens. By reducing the need to administer gabapentin from the thrice-daily administrations characteristic of immediate release gabapentin, the gastric rententive gabapentin dosage forms provided herein have the advantages of improving patient compliance for gabapentin treatment. In addition to the foregoing, the gastric rententive gabapentin dosages forms also exhibit decreased blood plasma concentrations and increased bioavailability throughout the dosing regimen.

La présente invention concerne un procédé pour le traitement d'un patient atteint d'une condition de douleur par l'administration au patient d'une forme posologique à rétention gastrique de gabapentine capable d'une administration en régimes de dosage d'une fois ou de deux fois par jour. Grâce à la réduction de la nécessité d'une administration trois fois par jour caractéristique de la libération immédiate de gabapentine, les formes posologiques de gabapentine à rétention gastrique ont l'avantage d'améliorer l'observance du patient pour le traitement à la gabapentine. En outre, les formes posologiques à rétention gastrique de gabapentine présentent également des concentrations réduites de plasma sanguin et une biodisponibilité accrue pendant toute la durée du régime de dosage.

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