Gastrin receptor-avid peptide conjugates

Details Gastrin receptor-avid peptide conjugates Gastrin receptor-avid peptide conjugates

C - Chemistry, Metallurgy

07

K

C07K 14/595 (2006.01) A61K 47/48 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07F 5/00 (2006.01) C07F 15/00 (2006.01) C07K 7/04 (2006.01) C07K 7/08 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2346154

A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

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