Gastrin releasing peptide antagonist

Details Gastrin releasing peptide antagonist Gastrin releasing peptide antagonist

C - Chemistry, Metallurgy

07

K

530/7.3, 167/103

C07K 14/575 (2006.01) A61K 38/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 1313157

F/4 5944P/5026A 17625 TITLE OF THE INVENTION GASTRIN RELEASING PEPTIDE ANTAGONIST ABSTRACT OF THE DISCLOSURE Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of heptapeptides that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.

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