Gastrointestinal mucosa-adherent matrixes, pharmaceutical...

Details Gastrointestinal mucosa-adherent matrixes, pharmaceutical... Gastrointestinal mucosa-adherent matrixes, pharmaceutical...

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2066384

A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.

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